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Course
on Natural Products |
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4.1 |
Syllabus on NATURAL PRODUCTS |
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a. |
Natural Products and the Biosphere |
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You can smell them, you may eat them |
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Some may heed them, the amorous will need them |
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Attract or repel sayeth the flora |
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Fight or flight respondth the fauna |
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b. |
Natural Products and Cancer |
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Colchicine, vincristine, vinblastine |
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Bleomycin, daunorubicin, mitomycin |
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Podophyllotoxin, camptothecin, taxol |
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Add the synthetics and you have it all |
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c. |
Natural Products against Malaria |
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Malaria the worst scourge the tropics have seen |
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Cinchona makes quinine, chemists chloroquine |
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But the pesky bug fought back for sure |
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Be ready with artemisinin or qinghaosu |
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d. |
Natural Products against Bacteria |
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On penicillin & cephalosporin we depend |
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But vancomycin is the last stand |
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Natural products of old come from dirt and sand |
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From sea or land, skin of frog or that of man |
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e. |
Natural Products and Insect Ecology |
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Sound or light we have not heard or seen |
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Ours is the world of polyketides and isoprene |
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For pheromones and scents, our senses are keen |
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To love, to survive and little ones to wean |
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f. |
Natural Products and Human Behaviour |
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From steroids to amphetamines |
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Cannabinoids to morphine |
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Use or abuse is up to the human being |
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But greater glory will yet be seen |
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g. |
Biosynthesis - the Common Thread |
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What ? a billion compounds to fill the universal void? |
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Fear not, my friend; principles to learn, pitfalls to avoid |
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Whether androstane, corticosteroid or alkaloid |
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Only two reactions to polyketides and three to terpenoids |
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Text : P.M. Dewick "Medicinal Natural Products" or
Mann "Secondary
Metabolism" & Selected Readings. |
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